Genomic Mutations Within the Host Microbiome: Adaptive Evolution or Purifying Selection. (January 2023)

• Record Type: Journal Article
• Authors: Zhang, Jiachao; Knight, Rob
• Is Part Of: Engineering. Volume 20(2023)
• Page Start: 96
• Page End: 102
• Publication Date: 2023-01
• Subjects: Gut microbiota -- Genomic mutations -- Adaptive evolution -- Purifying selection -- Single-nucleotide variants; Engineering -- Periodicals; Engineering -- China -- Periodicals; 620.005
• DOI: 10.1016/j.eng.2021.11.018
• Languages: English
• ISSNs: 2095-8099

Abstract

Abstract: Next-generation sequencing technology has transformed our ability to assess the taxonomic composition functions of host-associated microbiota and microbiomes. More human microbiome research projects—particularly those that explore genomic mutations within the microbiome—will be launched in the next decade. This review focuses on the coevolution of microbes within a microbiome, which shapes strain-level diversity both within and between host species. We also explore the correlation between microbial genomic mutations and common metabolic diseases, and the adaptive evolution of pathogens and probiotics during invasion and colonization. Finally, we discuss advances in methods and algorithms for annotating and analyzing microbial genomic mutations.