Developmental Trends of Peptide Drugs and Their Quality Assessment using Secondary Structure Analysis. Issue 11 (22nd March 2023)

• Record Type: Journal Article
• Authors: Misawa, Takashi; Demizu, Yosuke
• Is Part Of: ChemistrySelect. Volume 8:Issue 11(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-22
• Subjects: peptide drugs -- secondary structure -- quality assessment; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202300408
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Peptide‐based media is attracting attention as a new drug discovery modality. Medium‐sized peptide drugs possess the combinatorial properties of conventional small‐molecule drugs and biopharmaceuticals, such as antibodies. They are highly specific against target proteins, and they can be synthesized cost effectively. Because peptide drugs exhibit unique structural qualities, the standardization of manufacturing, quality evaluation, and safety assessment of these drugs are urgently required. In this regard, peptide drugs with several secondary structures have been developed, and evaluation of their secondary structures is considered key for their quality assessment. In this review, we introduce recent trends in the development of peptide therapeutics and methods for evaluating peptide drug structures. Abstract : Peptide‐based media is attracting attention as a new drug discovery modality. Because peptide drugs exhibit unique structural qualities, the standardization of manufacturing, quality evaluation, and safety assessment of these drugs are urgently required. Among them, the development of an assessment system for accurately evaluating the secondary structure of peptide drugs can contribute to ensuring their quality and safety. In this review, trends in the development of peptide drugs and several analytical methods to assess the secondary structure of peptides are introduced.