First Combined, Double‐Density LCV‐Pluronic F‐127 Radiochromic Dosimeter Mimicking Lungs and Muscles. Issue 6 (5th February 2023)

• Record Type: Journal Article
• Authors: Kozicki, Marek; Bartosiak, Marcin; Maras, Piotr; Wach, Radosław; Kadlubowski, Slawomir
• Is Part Of: Advanced materials technologies. Volume 8:Issue 6(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-05
• Subjects: combined dosimeter -- LCV‐Pluronic F‐127 -- radiotherapy dosimetry -- double‐tissue equivalent dosimeter -- lung‐mimicking dosimeter; Materials science -- Periodicals; Technological innovations -- Periodicals; Materials science; Technological innovations; Periodicals; 620.1105
• DOI: 10.1002/admt.202201023
• Languages: English
• ISSNs: 2365-709X

Abstract

Abstract: This work reports on a new type of combined radiochromic ionizing radiation dosimeter for radiotherapy. The LCV‐Pluronic F‐127 serves for this purpose, which is a leuco crystal violet embedded in a physical hydrogel matrix of poly(ethylene oxide)‐ block ‐poly(propylene oxide)‐ block ‐poly(ethylene oxide) (Pluronic F‐127) with additives. This dosimeter responds to ionizing radiation by developing a blue color with an intensity related to the radiation dose. The LCV‐Pluronic F‐127 dosimeter is improved for lower temperature stability by adding sodium chloride (NaCl). Subsequently, a method for manufacturing the LCV‐Pluronic F‐127 lung mimicking dosimeter is proposed. Next, the LCV‐Pluronic F‐127 3D composite dosimeter is elaborated, which contains in one container two dosimetric zones of different densities mimicking soft tissues: muscles and lungs. The following are investigated: i) LCV‐Pluronic F‐127 phase transition with and without NaCl, ii) dose response characteristics, iii) stability during storage, iv) foams characteristics – lung mimicking dosimeter, v) tissue equivalence, and vi) dose response of LCV‐Pluronic F‐127 combined dosimeter to a medical accelerator X‐ray irradiation. In summary, this work proves the possibility of formation complex dosimeters and opens a new area of research toward the development and application of such dosimeters containing dosimetric zones corresponding to many tissues in one vial. Abstract : The paper presents a new type of combined LCV‐Pluronic F‐127 radiochromic ionizing radiation dosimeter for radiotherapy. It consists of two dosimetric zones that mimic the muscles and lungs in one vial. The dosimeter reacts to ionizing radiation, producing a blue color. It is intended to be used to verify the treatment planning system calculated dose distributions in cancer eradication.