Coagulation dysfunction of severe burn patients: A potential cause of death. Issue 3 (May 2023)

• Record Type: Journal Article
• Authors: Zhang, Tie-ning; Ba, Te; Li, Fang; Chen, Qiang; Chen, Zhi-peng; Zhou, Biao; Yan, Zeng-qiang; Li, Quan; Cao, Sheng-jun; Wang, Ling-feng
• Is Part Of: Burns. Volume 49:Issue 3(2023)
• Page Start: 678
• Page End: 687
• Publication Date: 2023-05
• Subjects: Burn -- Coagulation dysfunction -- Inhalation injury -- Sepsis; Burns and scalds -- Periodicals; 617.11
• DOI: 10.1016/j.burns.2022.05.003
• Languages: English
• ISSNs: 0305-4179

Abstract

Abstract: Background: Research on coagulation dysfunction following burns is controversial. This study aimed to describe the coagulation changes in severe burn patients by examining coagulation parameters. Methods: Patients with third-degree total body surface area (TBSA) burns of ≥30% were enrolled between 2017 and 2020. Platelet (PLT) count and coagulation indexes (including APTT, INR, FIB, DD, and AT Ⅲ) were measured at admission and once weekly for 8 weeks, and statistical analysis was performed. The patient medical profiles were reviewed to extract demographic and clinical data, including TBSA, third-degree TBSA, and inhalation injury. The total intravenous fluids and transfusions of crystalloids, fresh frozen plasma (FFP), and red blood cells (RBC) were calculated during the forty-eight-hour period. The number of sepsis cases was recorded. Results: We enrolled 104 patients, and while the overall coagulation trend fluctuated, inflection points appeared around one week and demonstrated hypercoagulability. INR was significantly higher in the non-survival group than in the survivors' group from admission to three weeks after burn (all p <0.01). From post-injury week 1 to post-injury week 3, the APTT in the non-survival group was greater than in the survival group, but the non-survival group's PLT count was lower than that in the survival group (all p <0.05). At two and three weeks after burns, the FIB levels in the non-survival group were significantly lower than those of the survival group (both p <0.01). The prevalence of inhalation injury and the proportion of sepsis cases were significantly higher in the non-survival group than in the survival group ( p ＜ 0.05, p ＜ 0.001, respectively). At the time of death, APTT, INR, and FDP levels were significantly higher in the non-survival group in the survivor group, and FIB, ATIII, and PLT were significantly lower than in the survivor group (all p <0.01). On the day of death, nine of the 12 dead patients had disseminated intravascular coagulation (DIC). Conclusions: Coagulation dysfunction was most prominent in severe burn patients 1 week after injury and presented as hypercoagulability. Large-area burn injury, large amounts of fluid resuscitation, inhalation injury, and sepsis may all contribute to coagulation dysfunction, which can further develop into DIC and even death in severe burns patients. Highlights: The coagulation indexes of 104 patients with severe burns were analyzed over 8 weeks. The coagulation dysfunction of severe burns patients was most prominent at 1 week. Coagulation dysfunction is a contributing factor to the death of patients with severe burns.