Lutein production from microalgae: A review. (May 2023)

• Record Type: Journal Article
• Authors: Fu, Yunlei; Wang, Yinan; Yi, Lanbo; Liu, Jin; Yang, Shufang; Liu, Bin; Chen, Feng; Sun, Han
• Is Part Of: Bioresource technology. Volume 376(2023)
• Publication Date: 2023-05
• Subjects: Microalgae -- Lutein production -- Multi-stage cultivation -- Carbon metabolism -- Downstream process; Biomass -- Periodicals; Biomass energy -- Periodicals; Bioremediation -- Periodicals; Agricultural wastes -- Periodicals; Factory and trade waste -- Periodicals; Organic wastes -- Periodicals; Bioénergie -- Périodiques; Déchets agricoles -- Périodiques; Déchets industriels -- Périodiques; Déchets organiques -- Périodiques; Déchets (Combustible) -- Périodiques; 662.88
• DOI: 10.1016/j.biortech.2023.128875
• Languages: English
• ISSNs: 0960-8524

Abstract

Graphical abstract: Highlights: Cultivation conditions and strategies for lutein production are summarized. Metabolic and genetic designs for lutein biosynthesis are discussed. Two-stage strategy is efficient in enhancing lutein productivity. The in-situ lutein accumulation in fermenters is suggested to lower costs. Abstract: Lutein production from microalgae is a sustainable and economical strategy to offer the increasing global demands, but is still challenged with low lutein content at the high-cell density for commercial production. This review summarizes the suitable conditions for cell growth and lutein accumulation, and presents recent cultivation strategies to further improve lutein productivity. Light and nitrogen play critical roles in lutein biosynthesis that lead to the efficient multi-stage cultivation by increasing lutein content at the later stage. In addition, metabolic and genetic designs for carbon regulation and lutein biosynthesis are discussed at the molecule level. The in-situ lutein accumulation in fermenters by regulating carbon metabolism is considered as a cost-effective direction. Then, downstream processes are summarized for the efficient lutein recovery. Finally, challenges of current lutein production from microalgae are discussed. Meanwhile, potential solutions are proposed to improve lutein content and drive down costs of microalgal biomass.