Sense of vitality is associated with cardiovascular events in type 2 diabetes independently of traditional risk factors and arterial stiffness. Issue 2 (30th August 2022)

• Record Type: Journal Article
• Authors: Vergara, Marta; Östgren, Carl Johan; Nyström, Fredrik H.; Israelsson, Hanna
• Is Part Of: Diabetic medicine. Volume 40:Issue 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-30
• Subjects: cardiovascular diseases -- diabetes mellitus -- type 2 -- primary health care -- quality of life -- risk factors; Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.14938
• Languages: English
• ISSNs: 0742-3071

Abstract

Abstract: Aims: The aim of this study was to determine if single items in the quality of life questionnaire short form 36 (SF36) were associated with cardiovascular events in patients with type 2 diabetes mellitus (T2DM). Methods: In 756 T2DM patients (260 women) from the CARDIPP study, nine questions from the domains vitality and well‐being in SF36 were analysed. Patients, 55–66 years, were recruited in 2005–2008 and followed up until 31 December 2018 for the incidence of major adverse cardiovascular events (MACE), that is, myocardial infarction, stroke or cardiovascular death. Results: Median follow‐up time: 11.6 years, during which 119 (16%) MACE occurred. The SF36 items: 'seldom full of pep' (HR 1.2, 95% CI: 1.1–1.4, p = 0.006), 'seldom a lot of energy' (HR 1.3, 95%CI: 1.1–1.5, p < 0.001), 'worn out' (HR 1.2, 95%CI: 1.0–1.4, p = 0.020) and 'seldom happy' (HR 1.2, 95%CI: 1.0–1.4, p = 0.012) were independent risk factors for MACE in separate models, as well as male sex, diabetes duration, HbA1c, sagittal abdominal diameter and aortic pulse wave velocity. The variables 'seldom full of pep' and 'seldom a lot of energy' remained associated with MACE when conducting separate analyses for sexes. Only 'seldom a lot of energy' remained associated with MACE when all items from SF‐36 were comprised in the same model. Conclusions: One single question regarding energy levels from SF36 may be used as an independent risk factor for cardiovascular events in T2DM patients in primary care, for both men and women. This item may be included in future risk assessment for use in clinical practice for cardiovascular risk stratification of T2DM patients. Trial registration: The study was registered in clinicaltrial.gov (NCT 01049737) in 14 January 2010.