Front Cover: Homemade Solution of NaOD in D2O: Applications in the Field of Stilbene‐d1 Synthesis (Asian J. Org. Chem. 3/2023). Issue 3 (17th March 2023)

• Record Type: Journal Article
• Authors: Imai, Keisuke; Tomita, Naohito; Fujioka, Hiroyoshi; Kamiya, Mako; Ogasahara, Riku; Ban, Kazuho; Shimizu, Hyoga; Ishimoto, Takayoshi; Sajiki, Hironao; Akai, Shuji; Sawama, Yoshinari
• Is Part Of: Asian journal of organic chemistry. Volume 12:Issue 3(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-17
• Subjects: deuteration -- deuterium -- HWE reaction -- NaOD in D2O -- stilbene-d1; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202300084
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract : Although NaOD in D2 O is a valuable chemical reagent to prepare the deuterium‐incorporated products, it costs high. The cover picture shows that the simple and cost‐effective preparation of NaOD in D2 O from D2 O and t ‐BuONa was accomplished based on the salting‐out effect. The homemade NaOD in D2 O was used for the one‐pot synthesis of mono‐deuterated trans ‐stilbene (stilbene‐ d 1 ) in the aqueous Horner–Wadsworth–Emmons reaction. The mono‐deuterated trans ‐stilbenes were used to synthesize various deuterated compounds without a loss in the D content. More information can be found in the Research Article by Yoshinari Sawama et al .