Visible light mediated Iron-Catalyzed synthesis of C-3 alkylated Indoles, bisindolylmethanes and flavanones using alcohols. (12th April 2023)

• Record Type: Journal Article
• Authors: Waheed, Mohd; Alsharif, Meshari A; Issa Alahmdi, Mohammed; Mukhtar, Sayeed; Parveen, Humaira
• Is Part Of: Tetrahedron letters. Volume 119(2023)
• Publication Date: 2023-04-12
• Subjects: Visible light -- Knölker complex -- Aromatic primary alcohols -- C-3 alkylation of indole -- Bisindolylmethane; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2023.154428
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: An environmentally benign, mild approach for synthesis of C-3 alkylated indoles, bisindolylmethanes and flavanones using alcohols at room temperature under visible light has been developed. The reported reaction conditions were favorable for a wide range of alcohols afforded good to excellent yields of the respective products. Additionally, the reaction system was successfully extended to the synthesis of flavanones from 2-hydroxyacetophenone. The low cost and air stable Knölker iron catalyst has been employed for the dehydrogenation of alcohols under photolysis that would usually require a higher temperature.