It is time for ambitious, transformational change to the epidemic countermeasures ecosystem. Issue 10381 (25th March 2023) - Torreele, Els; McNab, Christine; Adeyi, Olusoji; Bonnell, Roxana; Dhaliwal, Mandeep; Hassan, Fatima; Kazatchkine, Michel; Kim, Hani; Kim, Jerome; Legido-Quigley, Helena; Liu, Joanne; Nishtar, Sania; et al.