Exercise induced bronchodilation: a phenomenon more common, greater magnitude and more prolonged in older adults than in adolescents. (4th May 2023)

• Record Type: Journal Article
• Authors: Welch, Ryan; Lardenoye, Mandy; Kolbe, John; Ellyett, Kevin
• Is Part Of: Journal of asthma. Volume 60:Number 5(2023)
• Page Start: 1016
• Page End: 1023
• Publication Date: 2023-05-04
• Subjects: Exercise -- bronchodilation -- respiratory -- physiology -- spirometry; Asthma -- Periodicals; 616.238005
• DOI: 10.1080/02770903.2022.2121719
• Languages: English
• ISSNs: 0277-0903

Abstract

Abstract: Objective: There are few studies in clinically healthy subjects describing and quantifying exercise-induced bronchodilation (EIBd ). This study aimed to describe and compare the magnitude and time course changes in post-exercise forced expired volume at the first second (FEV1 ) in healthy adolescents, younger adults, and older adults. Methods: Adolescent ( n = 73, aged 10–17 years), younger adult ( n = 35, aged 18–25 years), and older adult ( n = 25, aged 35–66 years) subjects with normal spirometry z-scores completed a maximal cardiopulmonary exercise test using the standardized exponential exercise test protocol on a cycle ergometer performed at stable temperature and humidity. Spirometry was performed pre-exercise and at 1-, 3-, 5-, and 10-minutes post-exercise to determine the percentage change in FEV1 compared to baseline. EIBd was defined as a ≥ 5% increase in post-exercise FEV1 . Results: Increases in FEV1 at one-minute post-exercise were observed in the adolescents (1.3%) and young adults (6.0%) with FEV1 returning to baseline after ten minutes. Compared to the adolescents, the older adults showed significantly greater and sustained increases in FEV1 at 1-, 3-, 5-, and 10-minutes post-exercise (6.4, 4.6, 4.7, and 3.8%, p < 0.05). At 1-minute post exercise a significantly greater proportion of younger adults (54%, p < 0.01) and older adults (64%, p < 0.01) demonstrated EIBd compared to the adolescent group (15%). Conclusion: Healthy older adults had a higher prevalence, greater magnitude and more prolonged EIBd compared to healthy adolescent and young adult subjects.