A Parotid Gland Mammary Analogue Secretory Carcinoma in a 4-Year-Old Boy: Case Report and Literature Review. (4th March 2023)

• Record Type: Journal Article
• Authors: Meng, Zhao; Si, Wu; Xiuli, Zhu; Liu, Yueping
• Is Part Of: Fetal and pediatric pathology. Volume 42:Number 2(2023)
• Page Start: 342
• Page End: 350
• Publication Date: 2023-03-04
• Subjects: Mammary analogue secretory carcinoma (MASC) -- salivary gland tumor -- ETV6-NTRK3 fusion -- pediatric patient; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2022.2116621
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Background: Mammary analogue secretory carcinoma (MASC) is characterized by similar histologic, immunohistochemical, and molecular features with breast secretory carcinoma. MASC usually occurs in adults. Case report: A 4-year-old boy presented with a right infra-auricular mass. Features of the tumor include solid, tubular, and papillary growth patterns, with homogenous eosinophilic secretions inside microcystic structures. Immunohistochemical stains showed strong, diffuse staining for CK7, S100, pan-TRK protein. P63 was positive in a peripheral pattern. Fluorescence in situ hybridization (FISH) analysis showed the characteristic ETV6-NTRK3 gene fusion. Conclusion: Typical histological, immunohistochemical, and molecular features are present in MASC occurring early in childhood.