Association of Placental Pathologic Findings with the Severity of Necrotizing Enterocolitis in Preterm infants – A Matched Case-Control Study. (4th March 2023)

• Record Type: Journal Article
• Authors: Garg, Parvesh Mohan; Paschal, Jaslyn L.; Ansari, Md Abu Yusuf; Billington, Lauren; Ware, Jennifer; Adams, Kristin; Hamda, Youssef Al; Oshunbade, Adebamike; Rosenfeld, Charles R.; Mir, Imran N.
• Is Part Of: Fetal and pediatric pathology. Volume 42:Number 2(2023)
• Page Start: 187
• Page End: 197
• Publication Date: 2023-03-04
• Subjects: Necrotizing enterocolitis -- preterm infants -- placental pathology; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2022.2110340
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Objective: To determine the association of placental pathology with the severity of necrotizing enterocolitis (NEC) in preterm infants. Methods: This single-center matched case-control study included infants with NEC ( n = 107) and gestational age and birth weight-matched controls ( n = 130), born between 2013 and 2020. Placentas were evaluated according to the Amsterdam Placental Workshop Group Consensus Statement. Results: Acute histologic chorioamnionitis with the fetal response was significantly more common in infants with surgical NEC vs. medical NEC (35.4% vs. 15.3%; p = 0.02). On regression model, infants with multiple placental pathologies (OR 2.16; 95% CI 1.01 − 4.73; p = 0.04) and maternal vascular malperfusion (OR 2.2; 95% CI 1.12 − 4.51; p = 0.02) had higher odds of either medical or surgical NEC than controls. Conclusion: Infants with multiple placental lesions, including placental inflammatory and vascular lesions, were at higher risk of medical or surgical NEC in the postnatal period.