Sucrose Nonfermenting-Related Kinase Expression Is Related to a Metabolic Switch in Ovarian Cancer Cells That Results in Increased Fatty Acid Oxidation. (21st April 2023)

• Record Type: Journal Article
• Authors: Chowdhury, Shreya; Ramchandran, Ramani; Palecek, Sean P.; Acevedo-Acevedo, Suehelay; Bishop, Erin
• Is Part Of: Cancer investigation. Volume 41:Number 4(2023)
• Page Start: 330
• Page End: 344
• Publication Date: 2023-04-21
• Subjects: Ovarian cancer -- metastasis -- omentum -- SNRK -- metabolism -- adipocytes -- mitochondria; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2022.2136376
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Ovarian cancer frequently metastasizes to the omentum, which is primarily comprised of adipocytes. Our previous study found that sucrose nonfermenting-related kinase (SNRK) expression is lower in advanced-stage compared with early-stage ovarian cancer tissue. In this study, SNRK knockdown was performed in ovarian cancer cell lines using lentiviral transduction and resulted in decreased cell proliferation, increased invasion, and a switch in metabolism to increased fatty acid oxidation (FAO). Our data suggest that SNRK works as a metabolic checkpoint that allows for oxidative phosphorylation and prevents FAO during a time of rapid tumor growth.