B cell activating factor (BAFF) selects IL-10−B cells over IL-10+B cells during inflammatory responses. (May 2017)

• Record Type: Journal Article
• Authors: Ma, Ning; Zhang, Yu; Liu, Qilin; Wang, Zhiding; Liu, Xiaoling; Zhu, Gaizhi; Yu, Dandan; Han, Gencheng; Chen, Guojiang; Hou, Chunmei; Wang, Tianxiao; Ma, Yuanfang; Shen, Beifen; Li, Yan; Xiao, He; Wang, Renxi
• Is Part Of: Molecular immunology. Volume 85(2017:May)
• Page Start: 18
• Page End: 26
• Publication Date: 2017-05
• Subjects: SLE systemic lupus erythematosus -- EAE Experimental allergic encephalomyelitis -- BAFF B-cell activating factor -- Bregs regulatory B cells; BAFF -- Regulatory B cells -- Inflammatory response -- EAE -- Lupus; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2017.02.002
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: Blockade of BAFF upregulates the percentage of IL-10 + Bregs in lupus-prone and EAE mice. BAFF selects IL-10 − over IL-10 + B cells for expansion during inflammatory responses. Selection of IL-10 − over IL-10 + B cells by BAFF were dependent on BAFF receptors. Abstract: B cell activating factor (BAFF) regulates B cell maturation, survival, function, and plays a critical pathogenic role in autoimmune diseases. It remains unclear how BAFF affects IL-10 − B cells versus regulatory B cells (Bregs) in inflammatory responses. In this study, we found that IL-10-expressing Bregs decreased in lupus-prone MRL/lpr mice and experimental allergic encephalomyelitis (EAE) mice. On blockade of the effects of BAFF with TACI-IgG, IL-10 + Bregs were upregulated in MRL/lpr and EAE mice. In addition, BAFF expanded IL-10 + B cells over IL-10 − B cells under noninflammatory conditions in vitro, whereas it expanded IL-10 − B cells over IL-10 + B cells during inflammatory responses, such as stimulation with autoantigen and LPS. Finally, the selection of IL-10 − B cells over IL-10 + B cells by BAFF was dependent on BAFF receptors (BAFFR, TACI, and BCMA) that were upregulated by inflammatory responses. This study suggests that BAFF selects IL-10 − B cells over IL-10 + regulatory B cells via BAFF receptors in inflammatory responses.