Immunomodulatory properties of D-sorbitol/D-mannitol incorporated linear step-growth Co-polymers. Issue 9 (13th June 2023)

• Record Type: Journal Article
• Authors: Kiran, S.; Parvathy, J.; Sukumaran, Thenmozhi; Varghese, Jeslin; Lakshmi, S; Kumar, Sreesha S.; Babu, Anu; Harikumar, Kuzhuvelil B.; Ragupathy, Lakshminarayanan
• Is Part Of: International journal of polymeric materials. Volume 72:Issue 9(2023)
• Page Start: 690
• Page End: 701
• Publication Date: 2023-06-13
• Subjects: D-mannitol/D-sorbitol based co-polymers -- toxicity studies -- immunomodulatory effects -- vaccine adjuvant); Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2022.2052726
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: A range of D-sorbitol/D-mannitol incorporated co-polymer s were synthesized via solvent free enzyme catalyzed polycondensation with adipic acid and polyethylene glycol. In-vitro cytotoxic studies on breast cancer and fibroblast cell lines showed that the co-polymer s are biocompatible up to 500 and 250 µg/mL, respectively. However, THP-1 and RAW 264.7 cell lines showed a dose dependent cytotoxicity. Furthermore, these co -polymers did not produce excessive cytokines (TNFα/IL-6) and chemokines (CXCL-5/CXCL-10) when interacting with THP-1 cells, thereby, not causing any inflammation. Whilst, the expression of IL-1b, CXCL-1 and IFNβ were upregulated. The results suggest that these co -polymers could be promising vaccine adjuvants. Graphical Abstract: UF0001