Relationship of Blood Pressure and White Matter Hyperintensity Burden With Level of and Change in Cognition in Older Black Adults. Issue 4 (22nd January 2022)
- Record Type:
- Journal Article
- Title:
- Relationship of Blood Pressure and White Matter Hyperintensity Burden With Level of and Change in Cognition in Older Black Adults. Issue 4 (22nd January 2022)
- Main Title:
- Relationship of Blood Pressure and White Matter Hyperintensity Burden With Level of and Change in Cognition in Older Black Adults
- Authors:
- Lamar, Melissa
Fleischman, Debra A.
Leurgans, Sue E.
Aggarwal, Neelum
Yu, Lei
Kim, Namhee
Poole, Victoria
Han, S. Duke
Arfanakis, Konstantinos
Barnes, Lisa L. - Abstract:
- ABSTRACT: Objective: Elevations in blood pressure (BP) and associated white matter hyperintensities (WMHs) are chronic comorbid conditions among older Black adults. We investigated whether WMHs modify the association between late-life BP and cognition within older Black adults. Methods: A total of 167 Black adults (age, ~75 years; without dementia at baseline) participating in neuroimaging studies at the Rush Alzheimer's Disease Center were evaluated for BP markers of cardiovascular health, including systolic BP, diastolic BP, pulse pressure, mean arterial pressure (MAP), and hypertension, and were assessed for global and domain-specific cognition at baseline and annually for up to 8 years. WMHs adjusted for intracranial volume were quantified at baseline. Results: Models adjusted for relevant confounders and the interaction of these variables with time revealed differential associations between BP markers and baseline cognition; however, only elevated diastolic BP predicted faster cognitive, that is, episodic memory, decline (estimate = −0.002, standard error = 0.0009, p = .002). Although WMH burden did not modify the association between diastolic BP and episodic memory decline, it did interact with diastolic BP to lower episodic memory at baseline (estimate = −0.051, standard error = 0.012, p = .0001); that is, greater WMHs combined with higher diastolic BP resulted in the lowest baseline episodic memory scores. A similar profile was noted for WMHs, MAP, and baselineABSTRACT: Objective: Elevations in blood pressure (BP) and associated white matter hyperintensities (WMHs) are chronic comorbid conditions among older Black adults. We investigated whether WMHs modify the association between late-life BP and cognition within older Black adults. Methods: A total of 167 Black adults (age, ~75 years; without dementia at baseline) participating in neuroimaging studies at the Rush Alzheimer's Disease Center were evaluated for BP markers of cardiovascular health, including systolic BP, diastolic BP, pulse pressure, mean arterial pressure (MAP), and hypertension, and were assessed for global and domain-specific cognition at baseline and annually for up to 8 years. WMHs adjusted for intracranial volume were quantified at baseline. Results: Models adjusted for relevant confounders and the interaction of these variables with time revealed differential associations between BP markers and baseline cognition; however, only elevated diastolic BP predicted faster cognitive, that is, episodic memory, decline (estimate = −0.002, standard error = 0.0009, p = .002). Although WMH burden did not modify the association between diastolic BP and episodic memory decline, it did interact with diastolic BP to lower episodic memory at baseline (estimate = −0.051, standard error = 0.012, p = .0001); that is, greater WMHs combined with higher diastolic BP resulted in the lowest baseline episodic memory scores. A similar profile was noted for WMHs, MAP, and baseline episodic memory. Hypertension was neither associated with cognition nor modified by WMH burden after multiple comparisons correction. Conclusion: Late-life diastolic BP was associated with faster rates of episodic memory decline in older Black adults; together with higher WMH burden, it (and MAP) lowered the point at which individuals begin their course of decline toward pathological aging. … (more)
- Is Part Of:
- Psychosomatic medicine. Volume 84:Issue 4(2022)
- Journal:
- Psychosomatic medicine
- Issue:
- Volume 84:Issue 4(2022)
- Issue Display:
- Volume 84, Issue 4 (2022)
- Year:
- 2022
- Volume:
- 84
- Issue:
- 4
- Issue Sort Value:
- 2022-0084-0004-0000
- Page Start:
- 437
- Page End:
- 445
- Publication Date:
- 2022-01-22
- Subjects:
- cognition -- longitudinal change -- blood pressure -- white matter -- aging -- blacks -- BMI = body mass index -- BP = blood pressure -- CI = confidence interval -- FLAIR = fluid-attenuated inversion recovery -- MAP = mean arterial pressure -- MARS = Minority Aging Research Study -- MPRAGE = magnetization-prepared rapid acquisition gradient-echo -- MRI = magnetic resonance imaging -- SE = standard error -- WMH = white matter hyperintensity
Medicine, Psychosomatic -- Periodicals
616.0805 - Journal URLs:
- http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=toc&SEARCH=00006842-000000000-00000.kc&LINKTYPE=asBody&LINKPOS=32&D=ovft ↗
http://www.psychosomaticmedicine.org ↗
http://journals.lww.com ↗ - DOI:
- 10.1097/PSY.0000000000001059 ↗
- Languages:
- English
- ISSNs:
- 0033-3174
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6946.555000
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British Library STI - ELD Digital store - Ingest File:
- 26835.xml