Amino Acid Uptake, Glucose Metabolism, and Neuroinflammation in John Cunningham Virus Associated Progressive Multifocal Leukoencephalopathy. (21st February 2022)

• Record Type: Journal Article
• Authors: Unterrainer, Marcus; Mahler, Christoph; Schumacher, Adrian-Minh; Ruf, Viktoria; Blum, Bernhard; Quach, Stefanie; Brendel, Matthias; Rupprecht, Rainer; Bartenstein, Peter; Kerschensteiner, Martin; Kümpfel, Tania; Albert, Nathalie L.
• Is Part Of: Clinical nuclear medicine. Volume 47:Number 6(2022)
• Page Start: 543
• Page End: 544
• Publication Date: 2022-02-21
• Subjects: FET -- FDG -- TSPO -- microglial activation -- John Cunningham virus -- PML; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000004093
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: A 69-year-old woman presented with progressive dysarthria and cognitive deficits. On MRI, a T2-hyperintense, non–contrast-enhancing lesion was found in the left precentral area. 18 F-FET and 18 F-FDG PET scans revealed faint amino acid uptake and glucose hypometabolism of the lesion. To assess a neuroinflammatory component, TSPO PET with 18 F-GE-180 was performed, where tracer uptake markedly exceeded the T2-hyperintense areas. Histology derived from a stereotactic biopsy findings confirmed John Cunningham virus–associated progressive multifocal leukoencephalopathy. This case underlines that TSPO PET comprises distinct imaging advantages over other established radioligands such as 18 F-FET and 18 F-FDG in progressive multifocal leukoencephalopathy.