Hydrogen-free palladium-catalyzed intramolecular anti-Markovnikov hydroaminocarbonylation of 2-(1-methylvinyl)anilines. Issue 25 (13th March 2023)

• Record Type: Journal Article
• Authors: Ru, Tong; Ning, Yingtang; Liu, Ding; Tao, Yuan; Wang, Jiaqi; Chen, Fen-Er
• Is Part Of: Chemical communications. Volume 59:Issue 25(2023)
• Page Start: 3755
• Page End: 3758
• Publication Date: 2023-03-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc06836b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The palladium-catalyzed intramolecular hydroaminocarbonylation of 2-(1-methylvinyl)aniline derivatives has been achieved using dppp (1, 3-bis(diphenylphosphino)propane) as a ligand under hydrogen-free conditions. Abstract : The palladium-catalyzed intramolecular hydroaminocarbonylation of 2-(1-methylvinyl)aniline derivatives has been achieved using dppp (1, 3-bis(diphenylphosphino)propane) as a ligand under hydrogen-free conditions. The reaction involves the generation of an active palladium hydride species with a catalytic amount of TsOH. This amide bond formation reaction was applied to the synthesis of various 4-substituted 3, 4-dihydroquinolone derivatives with both high yield and regioselectivity.