Visible-UVC upconversion polymer films for prevention of microbial infection. Issue 12 (7th March 2023)

• Record Type: Journal Article
• Authors: Zhao, Hang; Zhang, Liang; Lu, Jinsuo; Chai, Shouning; Wei, Jinliu; Yu, Yuning; Miao, Ruoyan; Zhong, Lvling
• Is Part Of: Journal of materials chemistry. Volume 11:Issue 12(2023)
• Page Start: 2745
• Page End: 2753
• Publication Date: 2023-03-07
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb01811j
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A wound dressing was prepared using upconversion powder (YSO-Pr) combined with polymer (PVA/SA) to convert visible light to UVC, demonstrating significant inhibition of a wide range of bacteria with no apparent side effects on human cells. Abstract : Bacterial infections caused by the growth and reproduction of pathogenic bacteria on wounds are one of the main reasons that hinder wound healing. Antibacterial wound dressings protect wounds from bacterial infections. Herein, we developed a polymeric antibacterial composite film using polyvinyl alcohol (PVA) and sodium alginate (SA) as the substrate. The film used praseodymium-doped yttrium orthosilicate (Y2 SiO5 : Pr 3+, YSO-Pr) to convert visible light into short-wavelength ultraviolet light (UVC) to kill bacteria. The YSO-Pr/PVA/SA showed upconversion luminescence in photoluminescence spectrometry tests, and the emitted UVC inhibited Gram-positive ( Staphylococcus aureus ) and Gram-negative ( Escherichia coli and Pseudomonas aeruginosa ) bacteria in antibacterial tests. In vivo animal tests showed that YSO-Pr/PVA/SA is effective and safe for inhibiting bacteria in real wounds. The in vitro cytotoxicity test further confirmed the good biocompatibility of the antibacterial film. In addition, YSO-Pr/PVA/SA exhibited sufficient tensile strength. Overall, this study demonstrates the potential of upconversion materials for use in medical dressings.