Intermittent fasting with ketogenic diet: A combination approach for management of chronic diseases. (April 2023)

• Record Type: Journal Article
• Authors: Arora, Niraj; Pulimamidi, Shruthi; Yadav, Hariom; Jain, Shalini; Glover, Jennifer; Dombrowski, Keith; Hernandez, Beverly; Sarma, Anand Karthik; Aneja, Rachna
• Is Part Of: Clinical nutrition ESPEN. Volume 54(2023)
• Page Start: 166
• Page End: 174
• Publication Date: 2023-04
• Subjects: Intermittent fasting -- Ketogenic diet -- Nutrition -- Neurological disorders -- Chronic conditions; IF Intermittent fasting -- KD ketogenic diet -- TRF Time-restricted fasting -- PF Periodic fasting -- DRF diet-restricted fasting -- MAD modified Atkins diet -- LGID Low glycemic index diet -- BDNF brain-derived neurotrophic factor; Nutritionally induced diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; 616.39005
• DOI: 10.1016/j.clnesp.2023.01.024
• Languages: English
• ISSNs: 2405-4577

Abstract

Summary: Intermittent Fasting (IF) is the consumption of food and drinks within a defined time, while the ketogenic diet (KD) switches the metabolism from glucose to fats. Continuation of intermittent fasting leads to the generation of ketones, the exact mechanism for a ketogenic diet. This article discusses the types of IF and KD, the monitoring required, and the mechanisms underlying IF and KD, followed by disorders in which the combination strategy could be applied. The strategies for successfully applying combination therapy are included, along with recommendations for the primary care physicians (PCP) which could serve as a handy guide for patient management. This opinion article could serve as the baseline for future clinical studies since there is an utmost need for developing new wholesome strategies for managing chronic disorders.