Diagnostic and prognostic biomarkers reflective of cardiac remodelling in diabetes mellitus: A scoping review. Issue 5 (28th February 2023)

• Record Type: Journal Article
• Authors: Chhor, Michael; Law, William; Pavlovic, Milan; Aksentijevic, Dunja; McGrath, Kristine; McClements, Lana
• Is Part Of: Diabetic medicine. Volume 40:Issue 5(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-28
• Subjects: biomarker -- cardiac fibrosis -- cardiovascular disease -- heart failure -- metabolomics -- scoping review; Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.15064
• Languages: English
• ISSNs: 0742-3071

Abstract

Abstract: Aims: The aim of this scoping review is to evaluate the current biomarkers used in the assessment of adverse cardiac remodelling in people with diabetes mellitus (DM) and in the diagnosis and prognosis of subsequent cardiovascular disease. We aim to discuss the biomarkers' pathophysiological roles as a reflection of the cardiac remodelling mechanisms in the presence of DM. Methods: We performed the literature search to include studies from 2003 to 2021 using the following databases: MEDLINE, Scopus, Web of Science, PubMed, and Cochrane library. Articles that met our inclusion criteria were screened and appraised before being included in this review. The PRISMA guidelines for Scoping Reviews were followed. Results: Our literature search identified a total of 43 eligible articles, which were included in this scoping review. We identified 15 different biomarkers, each described by at least two studies, that were used to determine signs of cardiac remodelling in cardiovascular disease (CVD) and people with DM. NT‐proBNP was identified as the most frequently employed biomarker in this context; however, we also identified emerging biomarkers including hs‐CRP, hs‐cTnT, and Galectin‐3. Conclusion: There is a complex relationship between DM and cardiovascular health, where more research is needed. Current biomarkers reflective of adverse cardiac remodelling in DM are often used to diagnose other CVDs, such as NT‐proBNP for heart failure. Hence there is a need for identification of specific biomarkers that can detect early signs of cardiac remodelling in the presence of DM. Further research into these biomarkers and mechanisms can deepen our understanding of their role in DM‐associated CVD and lead to better preventative therapies. Abstract : Patients with diabetes contain a two‐three‐fold increased risk of cardiovascular disease where the one of the earliest indicators of deteriorating cardiac health is cardiac remodelling. In this scoping review, we discovered fifteen potential biomarkers that may be used as therapeutic targets for early cardiac remodelling in patients with DM. Image created with Biorender.com.