In vivo genotoxicity of high-intensity intermediate frequency magnetic fields in somatic cells and germ cells. (29th December 2022)

• Record Type: Journal Article
• Authors: Ohtani, Shin; Ushiyama, Akira; Wada, Keiji; Suzuki, Yukihisa; Hattori, Kenji
• Is Part Of: Journal of radiation research. Volume 64:Number 2(2023)
• Page Start: 250
• Page End: 260
• Publication Date: 2022-12-29
• Subjects: intermediate frequency magnetic field (IF-MF) -- wireless power transfer system (WPT) -- genotoxicity -- somatic cell -- germ cell -- rodent; Radiology, Medical -- Periodicals; Radiobiology -- Periodicals; Radiation -- Periodicals; 616.0757
• DOI: 10.1093/jrr/rrac081
• Languages: English
• ISSNs: 0449-3060

Abstract

Abstract: Intermediate frequency magnetic fields (IF-MFs) at ~85 kHz are one of the components of wireless power transfer (WPT) systems. However, the available data needed for the assessment of the safety of organisms from IF-MF exposure are scarce. Thus, there is an imminent need to accumulate evidence-based assessment data. In particular, if humans are exposed to IF-MF due to an accident or trouble, they are at increased risk of being exposed to high-intensity IF-MF within a short period. The already existing exposure system was improved to a system that could intermittently expose animals at 3 s intervals. This system allows the exposure of a mouse to high-intensity IF-MF (frequency: 82.3 kHz; induced electric field: 87 V/m, which was 3.8 times the basic restriction level for occupational exposure in the ICNIRP guideline), while regulating the heat generated by the coil. In vivo genotoxicity after IF-MF exposure was assessed using micronucleus (MN) test, Pig-a assay, and gpt assay. The results of MN test and Pig-a assay in hematopoietic cells revealed that neither the reticulocytes nor the mature erythrocytes exhibited significant increases in the IF-MF-exposed group compared with that in the sham-exposed group. In germ cells, MN test and gpt assay outcomes showed that IF-MF exposure did not cause any genetic or chromosomal abnormality. Based on these data, there was no genotoxic effect of our set IF-MF exposure on somatic and germ cells. These findings can contribute to the widespread use of WPT systems as effective data of IF-MF safety assessment.