An injectable, natural peptide hydrogel with potent antimicrobial activity and excellent wound healing-promoting effects. (April 2023)

• Record Type: Journal Article
• Authors: Zhou, Jingjing; Cha, Ruitao; Wu, Zhiyu; Zhang, Chunliang; He, Yuhang; Zhang, Hanru; Liu, Kexin; Fareed, Muhammad Subaan; Wang, Zhaopeng; Yang, Changyan; Zhang, Yifan; Yan, Wenjin; Wang, Kairong
• Is Part Of: Nano today. Volume 49(2023)
• Publication Date: 2023-04
• Subjects: Antimicrobial peptide -- Jelleine-1 -- Peptide hydrogel -- Wound healing -- Biocompatibility -- Self-assembly; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2023.101801
• Languages: English
• ISSNs: 1748-0132

Abstract

Abstract: Wounds, especially refractory wounds infected by drug-resistant bacteria, threaten patients' health seriously. The development of wound dressings is urgently needed to address this problem. Herein, we report a peptide hydrogel formed by natural antimicrobial peptide Jelleine-1 and its potential use for MRSA -infected wounds. We studied the formation of Jelleine-1 hydrogel, its antimicrobial activity, biodegradability, biocompatibility, and wound healing effects. Our results showed that Jelleine-1 hydrogel was formed by the physical crosslinking of self-assembled Jelleine-1 nanofibers in PBS without any other chemical crosslinkers. It exhibited broad spectrum of antimicrobial activity and excellent biocompatibility. Notably, the hydrogel showed great potential in promoting wound healing in a mouse model with MRSA -infected burn wound. Our study would provide an inherent antimicrobial hydrogel dressing without loading antibiotics for wounds infected by drug-resistant bacteria, broaden the application of antimicrobial peptides, and pave an alternative strategy for the design of antimicrobial hydrogel. Graphical Abstract: ga1 Highlights: Jelleine-1 hydrogel was prepared in PBS without any other chemical cross-linker. Jelleine-1 hydrogel showed good injectable property and antimicrobial activity. Jelleine-1 hydrogel had excellent wound healing-promoting effect. Jelleine-1 hydrogel with good biocompatibility can be used as ideal wound dressings.