Hierarchical superparamagnetic metal–organic framework nanovectors as anti-inflammatory nanomedicines. Issue 14 (23rd March 2023)

• Record Type: Journal Article
• Authors: Zhao, Heng; Sene, Saad; Mielcarek, Angelika M.; Miraux, Sylvain; Menguy, Nicolas; Ihiawakrim, Dris; Ersen, Ovidiu; Péchoux, Christine; Guillou, Nathalie; Scola, Joseph; Grenèche, Jean-Marc; Nouar, Farid; Mura, Simona; Carn, Florent; Gazeau, Florence; Dumas, Eddy; Serre, Christian; Steunou, Nathalie
• Is Part Of: Journal of materials chemistry. Volume 11:Issue 14(2023)
• Page Start: 3195
• Page End: 3211
• Publication Date: 2023-03-23
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb02094g
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : We report a novel superparamagnetic stimuli-responsive nano-object coupling MIL-100(Fe) and maghemite, which, once combined with two complementary drugs (MTX and Dox), leads to a multifunctional theranostic platform to treat inflammatory diseases. Abstract : Among a plethora of drug nanocarriers, biocompatible nanoscale metal–organic frameworks (nanoMOFs) with a large surface area and an amphiphilic internal microenvironment have emerged as promising drug delivery platforms, mainly for cancer therapy. However, their application in biomedicine still suffers from shortcomings such as a limited chemical and/or colloidal stability and/or toxicity. Here, we report the design of a hierarchically porous nano-object (denoted as USPIO@MIL) combining a benchmark nanoMOF (that is, MIL-100(Fe)) and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles (that is, maghemite) that is synthesized through a one-pot, cost-effective and environmentally friendly protocol. The synergistic coupling of the physico-chemical and functional properties of both nanoparticles confers to these nano-objects valuable features such as high colloidal stability, high biodegradability, low toxicity, high drug loading capacity as well as stimuli-responsive drug release and superparamagnetic properties. This bimodal MIL-100(Fe)/maghemite nanocarrier once loaded with anti-tumoral and anti-inflammatory drugs (doxorubicin and methotrexate) shows high anti-inflammatory and anti-tumoral activities. In addition, the USPIO@MIL nano-object exhibits excellent relaxometric properties and its applicability as an efficient contrast agent for magnetic resonance imaging is herein demonstrated. This highlights the high potential of the maghemite@MOF composite integrating the functions of imaging and therapy as a theranostic anti-inflammatory formulation.