Hyponatremia as a Predictor of Cryptococcal Meningitis and Death Among Asymptomatic Persons With HIV and Cryptococcal Antigenemia. (28th March 2023)

• Record Type: Journal Article
• Authors: Lehman, Alice; Nalintya, Elizabeth; Wele, Abduljewad; Kirumira, Paul; Naluyima, Rose; Namuli, Teopista; Turya Musa, Fred; Skipper, Caleb P; Meya, David B; Boulware, David R; Rajasingham, Radha
• Is Part Of: Open forum infectious diseases. Volume 10:Number 3(2023)
• Publication Date: 2023-03-28
• Subjects: cryptococcal meningitis -- HIV -- hyponatremia; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofad156
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Among persons with human immunodeficiency virus–associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia.