Association Between the Development of Subclinical Cardiovascular Disease and Human Immunodeficiency Virus (HIV) Reservoir Markers in People With HIV on Suppressive Antiretroviral Therapy. (8th November 2022)

• Record Type: Journal Article
• Authors: Turcotte, Isabelle; El-Far, Mohamed; Sadouni, Manel; Chartrand-Lefebvre, Carl; Filali-Mouhim, Ali; Fromentin, Rémi; Chamberland, Annie; Jenabian, Mohammad-Ali; Baril, Jean-Guy; Trottier, Benoit; Thomas, Réjean; Tremblay, Cécile L; Durand, Madeleine; Chomont, Nicolas
• Is Part Of: Clinical infectious diseases. Volume 76:Number 7(2023)
• Page Start: 1318
• Page End: 1321
• Publication Date: 2022-11-08
• Subjects: HIV reservoir -- cardiovascular diseases -- HIV DNA -- atherosclerotic plaque -- aging; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac874
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: We report that people with human immunodeficiency virus (HIV) diagnosed with coronary artery atherosclerotic plaques display higher levels of HIV DNA compared with those without atherosclerotic plaques. In a multivariable prediction model that included 27 traditional and HIV-related risk factors, measures of HIV DNA were among the most important predictors of atherosclerotic plaque formation.