The role of IL-23/IL-17 axis in ischemic stroke from the perspective of gut-brain axis. (15th June 2023)

• Record Type: Journal Article
• Authors: Jiang, Yang; Dai, Yajie; Liu, Zhenquan; Liao, Yan; Sun, Shuyong; Kong, Xianghe; Hu, Jingjing; Tang, Yibo
• Is Part Of: Neuropharmacology. Volume 231(2023)
• Publication Date: 2023-06-15
• Subjects: Gut-brain axis -- Gut microbiota -- Ischemic stroke -- IL-23 -- IL-17 -- IL-17+T cells; CNS central nervous system -- EAE autoimmune encephalomyelitis -- MS multiple sclerosis -- IS ischemic stroke -- WHO World Health Organization -- DAMPs damage related molecular patterns -- HMGB1 high mobility group protein B1 -- ROS reactive oxygen species -- PRXs Peroxidase -- TLRs toll like receptors -- APCs antigen-presenting cells -- ENS enteric nervous system -- MCAO middle cerebral artery occlusion -- GABA γ-Aminobutyric acid -- 5-HT 5-hydroxytryptamine -- ECs Enterochromaffin Cells -- GLP-1 Glucagon like peptide -- OGD/R oxygen glucose deprivation/reperfusion -- DCs dendritic cells -- PAMPs pathogen associated molecular patterns -- BBB blood-brain barrier -- PPs Peyer's patches -- TJs tight junctions -- TREM1 triggering receptor expressed in myeloid cells 1 -- PRRs pattern recognition receptors -- IECs intestinal epithelial cells -- CLRs C-type lectin receptors -- FoxP3 forkhead box P3 -- mPFC medial prefrontal cortex -- BDNF brain-derived neurotrophic factor -- APP acute phase protein -- SAAs serum amyloid Proteins -- MBL mannose binding lectin -- CRP C-reactive protein -- SAP Stroke-associated pneumonia; Neuropsychopharmacology -- Periodicals; Autonomic Agents -- Periodicals; Neuropsychopharmacologie -- Périodiques; Neuropsychopharmacology; Periodicals; Electronic journals; 615.78
• DOI: 10.1016/j.neuropharm.2023.109505
• Languages: English
• ISSNs: 0028-3908

Abstract

Abstract: Bidirectional communication between central nervous system (CNS) and intestine is mediated by nerve, endocrine, immune and other pathways in gut–brain axis. Many diseases of CNS disturb the homeostasis of intestine and gut microbiota. Similarly, the dysbiosis of intestinal and gut microbiota also promotes the progression and deterioration of CNS diseases. IL-23/IL-17 axis is an important inflammatory axis which is widely involved in CNS diseases such as experimental autoimmune encephalomyelitis (EAE), multiple sclerosis (MS), and ischemic stroke (IS). Attributing to the long anatomically distances between ischemic brain and gut, previous studies on IL-23/IL-17 axis in IS are rarely focused on intestinal tissues. However, recent studies have found that IL-17 + T cells in CNS mainly originate from intestine. The activation and migration of IL-17 + T cells to CNS is likely to be affected by the altered intestinal homeostasis. These studies promoted the attention of IL-23/IL-17 axis and gut-brain axis. IS is difficult to treat because of its extremely complex pathological mechanism. This review mainly discusses the relationship between IL-23/IL-17 axis and IS from the perspective of gut-brain axis. By analyzing the immune pathways in gut-brain axis, the activation of IL-23/IL-17 axis, the roles of IL-23/IL-17 axis in gut, CNS and other systems after stoke, this review is expected to provide new enlightenments for the treatment strategies of IS. This article is part of the Special Issue on "Microbiome & the Brain: Mechanisms & Maladies". Highlights: IL-23/IL-17 (IL-23, IL-17, IL-17 + T cells) axis plays an important role in neuroinflammation after stroke. After stroke, the intestinal barrier is damaged, and then the translocated microflora activates intestinal immunity. There is growing evidence that IL-17 + T cells are activated in the intestine and then migrate to CNS. Translocated microflora and IL-17 + T cells may cause multiple-organ inflammatory injury.