Hair Cortisone Predicts Lower Stress-induced Salivary Cortisol Response: Resting-state Functional Connectivity Between Salience and Limbic Networks. (1st May 2023)

• Record Type: Journal Article
• Authors: Ren, Yipeng; Liu, Yadong; Zhao, Xiaolin; Hu, Weiyu; Wei, Zhenni; Tang, Zihan; Luo, Jiahao; Li, Mengyi; Guo, Kaige; Wu, Yan; Yang, Juan
• Is Part Of: Neuroscience. Volume 517(2023)
• Page Start: 61
• Page End: 69
• Publication Date: 2023-05-01
• Subjects: hair cortisone -- salivary cortisol -- resting-state functional connectivity -- limbic network -- salience network; ANOVA analysis of variance -- AUCg area under the curve with respect to the ground -- CI confidence interval -- CON control network -- DAN dorsal attention network -- DMN default mode network -- FD frame-wise displacement -- fMRI functional magnetic resonance imaging -- HairE hair cortisone -- HairF hair cortisol -- HPA hypothalamic–pituitaryadrenal -- LBN limbic network -- MRI magnetic resonance imaging -- PHG parahippocampus -- ROI region-of-interest -- RSFC resting-state functional connectivity -- SD standard deviation -- SMN somatomotor network -- SN salience network -- TPN temporal parietal network -- VN visual network; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2023.03.008
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Stress is an adaptive response to perceived threats in the environment. High hair cortisone can predict lower acute stress cortisol response. The RSFC between salience and limbic networks can mediate the association. The parahippocampus regulates stress and emotions. Abstract: Previous studies revealed that high long-term hypothalamic–pituitaryadrenal (HPA) axis activity measured by the hair cortisol concentrations predicts lower acute stress cortisol response and reported the influences of hair cortisol on brain activity during acute stress exposure. However, considering that long-term HPA axis activity has a close relationship with the brain's resting-state functional connectivity (RSFC), the current study aimed to explore the role of RSFC between limbic and salience network in this relationship. Seventy-seven healthy participants underwent resting-state imaging scans before performing the acute ScanSTRESS task. Saliva samples were collected to assess the levels of acute stress salivary cortisol. Hair samples were also collected, and the corticosteroid concentration extracted from these samples were used as a biomarker of long-term HPA axis activity. High hair cortisone (HairE) levels predicted lower acute stress cortisol response. Moreover, high HairE levels were significantly correlated with enhanced RSFC between limbic and salience networks, while RSFC was negatively associated with acute stress cortisol response. Importantly, the RSFC between left insula and left parahippocampus mediated the association between HairE and acute cortisol stress response. Taken together, this study uncovers the important role of RSFC between salience and limbic networks in the long-term relationship between HairE and acute cortisol response and contributes to a deeper understanding of the individual differences in acute stress response.