Trajectories of IgE sensitization to allergen molecules from childhood to adulthood and respiratory health in the EGEA cohort. Issue 2 (8th July 2021)

• Record Type: Journal Article
• Authors: Siroux, Valérie; Boudier, Anne; Bousquet, Jean; Dumas, Orianne; Just, Jocelyne; Le Moual, Nicole; Nadif, Rachel; Varraso, Raphaëlle; Valenta, Rudolf; Pin, Isabelle
• Is Part Of: Allergy. Volume 77:Issue 2(2022)
• Page Start: 609
• Page End: 618
• Publication Date: 2021-07-08
• Subjects: asthma -- epidemiology -- IgE; Allergy -- Periodicals; 616.97
• DOI: 10.1111/all.14987
• Languages: English
• ISSNs: 0105-4538

Abstract

Abstract: Background: Longitudinal studies assessing the association of profiles of allergen‐specific IgE (sIgE) sensitization to a large range of allergen molecules and respiratory health are rare. We aimed to assess trajectories of molecular sIgE sensitization profiles from childhood to adulthood and their associations with respiratory health. Methods: IgE reactivity to microarrayed allergen molecules were measured in childhood (EGEA1) and 12 years later in adult life (EGEA2) among 291 EGEA participants (152 with asthma). At each time point, sIgE sensitization profiles were identified by latent class analysis (LCA) by considering IgE‐reactivity to the 38 most prevalent respiratory allergens. The LCA‐defined profiles were then studied in association with respiratory health. Results: At baseline, the mean (min‐max) age of the population was 11 (4.5–16) years. The LCA identified four sIgE sensitization profiles which were very similar at both time points (% at EGEA1 and EGEA2); A: "no/few allergen(s)" (48%, 39%), B: "pollen/animal allergens" (18%, 21%), C: "most prevalent house dust mite allergens" (22%, 27%) and D: "many allergens" (12%, 13%). Overall, 73% of the participants remained in the same profile from childhood to adulthood. The profiles were associated with asthma and rhinitis phenotypes. Participants of profiles C and D had lower FEV1 % and FEF25‐75 % as compared to profile A. Similar patterns of associations were observed for participants with asthma. There was no association with change in lung function. Conclusion: Using high‐resolution sIgE longitudinal data, the LCA identified four molecular sensitization profiles, mainly stable from childhood to adulthood, that were associated with respiratory health. Abstract : This study, using high resolution allergen‐specific IgE longitudinal data, identified four molecular sensitization profiles that were mainly stable from childhood to adulthood. The identified profiles were associated with asthma and rhinitis phenotypes, eosinophil counts, FEV1 level and FEF25‐75 level. Our findings suggest that IgE‐reactivity towards a large set of respiratory allergen molecules may be summarized by four clinically meaningful sIgE sensitization profiles. Abbreviations: EGEA, The Epidemiological Study on the Genetics and Environmment of Asthma; FEV1, forced expiratory volume in 1 second; FEF, forced expiratory flow at 25–75% of forced vital capacity