Birdshot Chorioretinopathy: Resistant versus Responsive. (16th March 2023)

• Record Type: Journal Article
• Authors: Maleki, Arash; Look-Why, Sydney; Manhapra, Ambika; Asgari, Soheila; Garcia, Cristina M.; Al-Dabbagh, Alaa; Tsang, Catherine; Chang, Peter Y.; Anesi, Stephen D.; Foster, C. Stephen
• Is Part Of: Ocular immunology and inflammation. Volume 31:Number 3(2023)
• Page Start: 477
• Page End: 482
• Publication Date: 2023-03-16
• Subjects: Biologic response modifier -- birdshot chorioretinopathy -- BSCR -- corticosteroid -- electroretinography -- fluorescein angiography -- immunomodulatory therapy -- indocyanine green angiography -- retinal vasculitis -- visual field -- short wavelength automated perimetry; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2022.2032193
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To search findings that can explain the heterogeneity between Resistant and Responsive patients with birdshot chorioretinopathy. Patients and Methods: This was a retrospective observational case series on "Responsive" versus "Resistant" birdshot chorioretinopathy Results: One-hundred-eighty and Ninety-nine patients were included in the Responsive and Resistant groups respectively. Multivariate analysis of paraclinical variables at the first visit demonstrated that mean deviation (p = .04), pattern standard deviation (p < .001), optic nerve head leakage (p = .012), large vessel leakage and staining (p = .01), and macular small vessel leakage (p = .03) were statistically significantly different between the two groups; however, at the visit preceding successful therapy, only macular small vessel leakage (p = .01) was statistically significantly different between the two groups Conclusion: .Small vessel leakage in the macular area and/or optic nerve head leakage at the earliest visit might be risk factors for resistant birdshot chorioretinopathy.