Activation of Parabrachial Tachykinin 1 Neurons Counteracts Some Behaviors Mediated by Parabrachial Calcitonin Gene-related Peptide Neurons. (1st May 2023)

• Record Type: Journal Article
• Authors: Arthurs, Joe W.; Pauli, Jordan L.; Palmiter, Richard D.
• Is Part Of: Neuroscience. Volume 517(2023)
• Page Start: 105
• Page End: 116
• Publication Date: 2023-05-01
• Subjects: conditioned taste aversion -- escape -- freezing -- threat response -- avoidance -- INTRSECT; ac anterior commissure -- AP anterior-posterior axis -- BLA basolateral amygdala -- BLP basolateral amygdaloid nucleus posterior part -- BNST bed nucleus of the stria terminalis -- BNSTov bed nucleus of the stria terminalis oval nucleus -- BNSTv bed nucleus of the stria terminalis ventral nucleus -- Calca gene that encodes calcitonin-gene related peptide -- CeA central nucleus of the amygdala -- CeC Central nucleus of the amygdala lateral capsular part -- CeL central nucleus of the amygdala lateral part -- CeM central nucleus of the amygdala medial part -- CGRP calcitonin gene-related peptide -- CM central medial nucleus of the thalamus -- CNO clozapine-N-oxide -- CS conditioned stimulus -- CTA conditioned taste aversion -- DV dorsal-ventral axis -- IP Intraperitoneal -- GDF15 growth differentiation factor 15 -- IC insular cortex -- IMD intermediodorsal nucleus of the thalamus -- LiCl lithium chloride -- LSV lateral septal nucleus ventral part -- LSI lateral septal nucleus intermediate part -- MdD medullary reticular nucleus dorsal part -- ML medial-lateral axis -- MS medial septal nucleus -- NTS neurotensin -- PBN parabrachial nucleus -- PBS phosphate buffered saline -- PSTN parasubthalamic nucleus -- PVT paraventricular nucleus -- Re reuniens thalamic nucleus -- Rh rhomboid thalamic nucleus -- scp superior cerebellar peduncle -- SH septohippocampal nucleus -- Tac1 tachykinin 1 -- Tacr1 tachykinin 1 receptor -- US unconditioned stimulus -- VPMpc ventroposteriormedial thalamic nucleus parvocellular part; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2023.03.003
• Languages: English
• ISSNs: 0306-4522

Abstract

Graphical abstract: Highlights: Activation of Tac1 PBN neurons promotes escape, not freezing. Activation of Tac1 PBN neurons does not elicit conditioned taste aversion (CTA). Activation of Tac1 PBN neurons blocks CTA generated by LiCl or CGRP PBN activation. Activation of Tac1+;CGRP− via INTRSECT replicates Tac1 PBN activation. Abstract: Many threats activate parabrachial neurons expressing calcitonin gene-related peptide (CGRP PBN ) which transmit alarm signals to forebrain regions. Most CGRP PBN neurons also express tachykinin 1 (Tac1), but there are also Tac1-expressing neurons in the PBN that do not express CGRP (Tac1+;CGRP− neurons). Chemogenetic or optogenetic activation of all Tac1 PBN neurons in mice elicited many physiological/behavioral responses resembling the activation of CGRP PBN neurons, e.g., anorexia, jumping on a hot plate, avoidance of photostimulation; however, two key responses opposed activation of CGRP PBN neurons. Activating Tac1 PBN neurons did not produce conditioned taste aversion and it elicited dynamic escape behaviors rather than freezing. Activating Tac1+;CGRP− neurons, using an intersectional genetic targeting approach, resembles activating all Tac1 PBN neurons. These results reveal that activation of Tac1+;CGRP− neurons can suppress some functions attributed to the CGRP PBN neurons, which provides a mechanism to bias behavioral responses to threats.