Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System (Adv. Sci. 4/2022). Issue 4 (3rd February 2022)

• Record Type: Journal Article
• Authors: Kotla, Niranjan G.; Isa, Isma Liza Mohd; Rasala, Swetha; Demir, Secil; Singh, Rajbir; Baby, Becca V.; Swamy, Samantha K.; Dockery, Peter; Jala, Venkatakrishna R.; Rochev, Yury; Pandit, Abhay
• Is Part Of: Advanced science. Volume 9:Issue 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-03
• Subjects: Science -- Periodicals; 505
• DOI: 10.1002/advs.202270025
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : Colon Mucosa Protecting HA‐Enema System In article number 2103189, Yury Rochev, Abhay Pandit, and co‐workers develop a biphasic HMW‐hyaluronan (HA) enema suspension that protects the dysregulated colitis colon epithelium. The developed HA‐based system modulate the intestinal epithelial junctional proteins and regulatory signalling pathways, resulting in attenuation of inflammation and mucosal protection. Furthermore, the developed system helps restore the dysregulated intestinal barrier functions and helps in distal colitis management.