Estimating HLA haplotype frequencies from homozygous individuals – A Technical Report. (27th September 2021)

• Record Type: Journal Article
• Authors: Seitz, Susanne; Lange, Vinzenz; Norman, Paul J.; Sauter, Jürgen; Schmidt, Alexander H.
• Is Part Of: International journal of immunogenetics. Volume 48:Number 6(2021)
• Page Start: 490
• Page End: 495
• Publication Date: 2021-09-27
• Subjects: allele frequency -- donor registry -- haplotype frequency -- HLA -- homozygosity; Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12553
• Languages: English
• ISSNs: 1744-3121

Abstract

Abstract: We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation‐maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.