Postpartum fevers, a rare presentation of secondary hemophagocytic lymphohistiocytosis. Issue 3 (17th March 2023)

• Record Type: Journal Article
• Authors: Lee, Jacqueline; Pham, Brian; Karanjawala, Zarir E.; Adesina, Oyebimpe
• Is Part Of: Clinical case reports. Volume 11:Issue 3(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-17
• Subjects: anakinra -- fever of unknown origin -- hemophagocytic lymphohistiocytosis -- postpartum fevers; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.7070
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare disease of excessive immune system activation. We report a case of HLH in a 20‐year‐old primigravid woman who presented with postpartum fevers. She was successfully treated with dexamethasone and anakinra, a deviation from the HLH‐94 protocol, to preserve her ability to breastfeed. Abstract : HLH is an important differential diagnosis for postpartum fevers, cytopenias, and elevated liver enzymes. To treat postpartum HLH, anakinra and dexamethasone may be a reasonable alternative to the HLH‐94 protocol in patients who wish to breastfeed