Establishing cognitive baseline in three generations: Framingham Heart Study. Issue 1 (24th March 2023)

• Record Type: Journal Article
• Authors: Yang, Jin; Ang, Ting Fang Alvin; Lu, Sophia; Liu, Xue; Devine, Sherral; Au, Rhoda; Liu, Chunyu
• Is Part Of: Alzheimer's & dementia. Volume 15:Issue 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-24
• Subjects: Alzheimer's disease -- cognitive function -- dementia -- neuropsychological test -- norms; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1002/dad2.12416
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: Generational changes warrant recalibrating normative cognitive measures to detect changes indicative of dementia risk within each generation. Methods: We performed linear regressions to compare eight neuropsychological (NP) tests among three‐generation cohorts at baseline in Framingham Heart Study (FHS, n = 4787) and conducted Cox regressions to investigate the relationships of NP tests with generation‐specific dementia risk. Results: The FHS second and third generations performed better than the first generation for seven NP tests (0.14–0.81 standard deviation improvement, P ≤ .001) while the second and third generations performed similarly for six of eight NP tests ( P > .05). One standard deviation better performance was associated with a higher reduction in incident dementia risk in the second than the first generation (35% vs. 24%, P interaction = .02) for the similarities test. Discussion: Our findings suggest cohort‐based norms are needed for cognitive assessment for the diagnosis of cognitive impairment and dementia.