Predicting 1-year in-stent restenosis in superficial femoral arteries through multiscale computational modelling. Issue 201 (5th April 2023)

• Record Type: Journal Article
• Authors: Corti, Anna; Migliavacca, Francesco; Berceli, Scott A.; Chiastra, Claudio
• Is Part Of: Journal of the Royal Society interface. Volume 20:Issue 201(2023)
• Publication Date: 2023-04-05
• Subjects: lower-limb peripheral arteries -- in-stent restenosis -- computational modelling -- agent-based modelling -- computational fluid dynamics -- mechanobiology; Physical sciences -- Research -- Periodicals; Life sciences -- Research -- Periodicals; Interdisciplinary research -- Periodicals; 570.5
• DOI: 10.1098/rsif.2022.0876
• Languages: English
• ISSNs: 1742-5689

Abstract

Abstract : In-stent restenosis in superficial femoral arteries (SFAs) is a complex, multi-factorial and multiscale vascular adaptation process whose thorough understanding is still lacking. Multiscale computational agent-based modelling has recently emerged as a promising approach to decipher mechanobiological mechanisms driving the arterial response to the endovascular intervention. However, the long-term arterial response has never been investigated with this approach, although being of fundamental relevance. In this context, this study investigates the 1-year post-operative arterial wall remodelling in three patient-specific stented SFA lesions through a fully coupled multiscale agent-based modelling framework. The framework integrates the effects of local haemodynamics and monocyte gene expression data on cellular dynamics through a bi-directional coupling of computational fluid dynamics simulations with an agent-based model of cellular activities. The framework was calibrated on the follow-up data at 1 month and 6 months of one stented SFA lesion and then applied to the other two lesions. The calibrated framework successfully captured (i) the high lumen area reduction occurring within the first post-operative month and (ii) the stabilization of the median lumen area from 1-month to 1-year follow-ups in all the stented lesions, demonstrating the potentialities of the proposed approach for investigating patient-specific short- and long-term responses to endovascular interventions.