Immunomodulation with Nucleic Acid Nanodevices. Issue 14 (4th January 2023)

• Record Type: Journal Article
• Authors: Ding, Fei; Zhang, Shuangye; Chen, Qian; Feng, Hao; Ge, Zhilei; Zuo, Xiaolei; Fan, Chunhai; Li, Qian; Xia, Qiang
• Is Part Of: Small. Volume 19:Issue 14(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-04
• Subjects: immunomodulation -- innate immunity -- nucleic acid delivery -- nucleic acid nanodevices -- nucleic acid nanotechnology; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202206228
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: The precise regulation of interactions of specific immunological components is crucial for controllable immunomodulation, yet it remains a great challenge. With the assistance of advanced computer design, programmable nucleic acid nanotechnology enables the customization of synthetic nucleic acid nanodevices with unprecedented geometrical and functional precision, which have shown promising potential for precise immunoengineering. Notably, the inherently immunologic functions of nucleic acids endow these nucleic acid‐based assemblies with innate advantages in immunomodulatory engagement. In this review, the roles of nucleic acids in innate immunity are discussed, focusing on the definition, immunologic modularity, and enhanced bioavailability of structural nucleic acid nanodevices. In light of this, molecular programming and precise organization of functional modules with nucleic acid nanodevices for immunomodulation are emphatically reviewed. At last, the present challenges and future perspectives of nucleic acid nanodevices for immunomodulation are discussed. Abstract : Programing Watson–Crick base pairing with the aid of advanced computer design empowers the customization of synthetic nucleic acid nanodevices with unprecedented geometrical and functional precision, thus permitting precise regulation of the interactions with specific biological components. In this review, recent advances in immunomodulation with nucleic acid nanodevices are summarized and future perspectives are proposed.