Neuroprotective Effects of N-acetylserotonin and Its Derivative. (1st May 2023)

• Record Type: Journal Article
• Authors: Kang, Ji-He; Guo, Xu-Dong; Wang, Yi-Dian; Kang, Xue-Wen
• Is Part Of: Neuroscience. Volume 517(2023)
• Page Start: 18
• Page End: 25
• Publication Date: 2023-05-01
• Subjects: N-acetylserotonin -- neuroprotection -- oxidative stress -- apoptosis -- inflammation; AANAT arylalkylamine N-acetyltransferase -- BDNF brain-derived neurotrophic factor -- cAMP cyclic adenosine monophosphate -- CREB cAMP response element binding protein -- NAS N-acetylserotonin -- NE norepinephrine -- SCN suprachiasmatic nucleus -- TrkB tyrosine kinase receptor B; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2023.02.017
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: NAS and HIOC are neuroprotective agents. NAS and HIOC are anti-oxidative stress and anti-inflammatory. NAS and HIOC counteract autophagy dysfunction and apoptosis. NAS and HIOC may show usefulness in clinical trials. Abstract: N-acetylserotonin (NAS) is a chemical intermediate in melatonin biosynthesis. NAS and its derivative N-(2-(5-hydroxy-1H-indol-3-yl) ethyl)-2-oxopiperidine-3-carboxamide (HIOC) are potential therapeutic agents for traumatic brain injury, autoimmune encephalomyelitis, hypoxic-ischemic encephalopathy, and other diseases. Evidence shows that NAS and its derivative HIOC have neuroprotective properties, and can exert neuroprotective effects by inhibiting oxidative stress, anti-apoptosis, regulating autophagy dysfunction, and anti-inflammatory. In this review, we discussed the neuroprotective effects and related mechanisms of NAS and its derivative HIOC to provide a reference for follow-up research and applications.