Mesocrystalline ZnS nanoparticles-augmented sonocatalytic full water splitting into H2/O2 for immunoactivating deep tumor. (May 2023)

• Record Type: Journal Article
• Authors: Xia, Chao; Wu, Anbang; Jin, Zhaokui; Zeng, Lingting; Jiang, Lingdong; Xu, Qingqing; Fan, Mingjian; He, Qianjun
• Is Part Of: Biomaterials. Volume 296(2023)
• Publication Date: 2023-05
• Subjects: Sonocatalysis -- Nanomedicine -- Controlled release -- Hydrogen/oxygen therapy -- Immune activation -- Hypoxia -- Deep tumor; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2023.122090
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Therapeutic gas molecules have high tissue penetrability, but their sustainable supply and controlled release in deep tumor is a huge challenge. In this work, a concept of sonocatalytic full water splitting for hydrogen/oxygen immunotherapy of deep tumor is proposed, and a new kind of ZnS nanoparticles with a mesocrystalline structure (mZnS) is developed to achieve highly efficient sonocatalytic full water splitting for sustainable supply of H2 and O2 in tumor, achieving a high efficacy of deep tumor therapy. Mechanistically, locally generated hydrogen and oxygen molecules exhibit a tumoricidal effect as well as the co-immunoactivation of deep tumors through inducing the M2-to-M1 repolarization of intratumoral macrophages and the tumor hypoxia relief-mediated activation of CD8 + T cells, respectively. The proposed sonocatalytic immunoactivation strategy will open a new window to realize safe and efficient treatment of deep tumors. Highlights: A novel therapeutic concept of sonocatalytic full water splitting for H2 /O2 immunotherapy of deep tumor is proposed. A mesocrystalline structure of ZnS is developed to realize highly efficient sonocatalytic H2 /O2 therapy of deep tumor. A new mechanism of hydrogen/oxygen co-immunoactivation of deep tumors is discovered.