Thoracic Air Leak Syndrome, Pulmonary Aspergillosis, and COVID-19 Pneumonia After Allogeneic Stem Cell Transplantation in a Child With Myelodysplastic Syndrome. Issue 2 (March 2022)

• Record Type: Journal Article
• Authors: Sever, Tayyibe; Kaya, Zuhre; Kirkiz, Serap; Celik, Ali; Akdulum, Ismail; Gürsoy, Tugba R.; Aslan, Ayse T.; Deniz, Melis; Tapisiz, Anil; Kocak, Ulker
• Is Part Of: Journal of pediatric hematology/oncology. Volume 44:Issue 2(2022)
• Publication Date: 2022-03
• Subjects: bronchiolitis obliterans -- COVID-19 -- pulmonary aspergillosis -- stem cell transplantation -- thoracic air leak syndrome; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000002203
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Thoracic air leak syndromes (TALS) are very rare among the noninfectious pulmonary complications (PCs). They can either be idiopathic or have several risk factors such as allogeneic hematopoietic stem cell transplantation (allo-HSCT), graft versus host disease and rarely pulmonary aspergillosis. We present a 14-year-old girl with hypoplastic myelodysplastic syndrome who developed graft versus host disease on day 60, TALS on day 150, bronchiolitis obliterans syndrome on day 300, pulmonary aspergillosis on day 400 and COVID-19 pneumonia on day 575 after allo-HSCT. This is the first report of a child who developed these subsequent PCs after allo-HSCT. Therefore, the manifestations of these unfamiliar PCs like TALS and COVID-19 pneumonia, and concomitant pulmonary aspergillosis with management options are discussed.