Speech patterns and enunciation for encephalopathy determination—A prospective study of hepatic encephalopathy. Issue 10 (21st July 2022)

• Record Type: Journal Article
• Authors: Moon, Andrew M.; Kim, Hannah P.; Cook, Sarah; Blanchard, Renee T.; Haley, Katarina L.; Jacks, Adam; Shafer, Jennifer S.; Fried, Michael W.
• Is Part Of: Hepatology communications. Volume 6:Issue 10(2022)
• Page Start: 2876
• Page End: 2885
• Publication Date: 2022-07-21
• Subjects: Hepatology -- Periodicals; Liver -- Diseases -- Periodicals; Liver Diseases; Gastroenterology; Periodicals; Fulltext; Internet Resources; Periodicals; 616.36
• DOI: 10.1002/hep4.2054
• Languages: English
• ISSNs: 2471-254X

Abstract

Abstract: Hepatic encephalopathy (HE) is a complication of cirrhosis that benefits from early diagnosis and treatment. We aimed to characterize speech patterns of individuals with HE to investigate its potential to diagnose and monitor HE. This was a single‐center prospective cohort study that included participants with cirrhosis with HE (minimal HE [MHE] and overt HE [OHE]), cirrhosis without HE, and participants without liver disease. Audio recordings of reading, sentence repetition, and picture description tasks were obtained from these groups. Two certified speech‐language pathologists assessed speech rate (words per minute) and articulatory precision. An overall severity metric was derived from these measures. Cross‐sectional analyses were performed using nonparametric Wilcoxon statistics to evaluate group differences. Change over time in speech measures was analyzed descriptively for individuals with HE. The study included 43 total participants. Speech results differed by task, but the overall pattern showed slower speech rate and less precise articulation in participants with OHE compared to other groups. When speech rate and precision ratings were combined into a single speech severity metric, the impairment of participants with OHE was more severe than all other groups, and MHE had greater speech impairment than non‐liver disease controls. As OHE improved clinically, participants showed notable improvement in speech rate. Participants with OHE demonstrated impaired speech rate, precision, and speech severity compared with non‐liver disease and non‐HE cirrhosis. Participants with MHE had less pronounced impairments. Speech parameters improved as HE clinically improved. Conclusion : These data identify speech patterns that could improve HE diagnosis, grading, and remote monitoring. Abstract : image In this prospective observational study, we performed audio recordings of reading, sentence repetition and picture description tasks for patients with overt hepatic encephalopathy (HE), minimal HE, cirrhosis without HE and participants without liver disease. Overt HE participants demonstrated impaired speech rate, precision and overall speech severity compared to non‐liver disease controls and non‐HE cirrhosis and these parameters improved substantially as overt HE improved. These findings provide important early evidence that monitoring of speech is feasible in the inpatient setting and could be used to diagnose, stage, and monitor both overt and minimal HE.