Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels. Issue 4 (12th April 2023)

• Record Type: Journal Article
• Authors: AlGhamdi, Shareefa A.; Al-Abbasi, Fahad A.; Alghamdi, Amira M.; Omer, Asma B.; Afzal, Obaid; Altamimi, Abdulmalik S. A.; Alamri, Abdulaziz; Alzarea, Sami I.; Almalki, Waleed Hassan; Kazmi, Imran
• Is Part Of: Royal Society open science. Volume 10:Issue 4(2023)
• Publication Date: 2023-04-12
• Subjects: dementia -- flavonoids -- isoflavone -- neuroprotective; Science -- Periodicals; 500
• DOI: 10.1098/rsos.230013
• Languages: English
• ISSNs: 2054-5703

Abstract

Abstract : The current study was designed for the evaluation of barbigerone on memory loss. In this experimental study, 24 Wistar rats ( n = 6) were used. Control rats and scopolamine (SCOP)-treated control group rats were orally administered with 3 ml of 0.5% sodium carboxymethyl cellulose (vehicle), whereas barbigerone was (10 and 20 mg kg −1 ) administered orally to the rats from the test group. During the 14-day treatment, control group rats were given 3 ml kg −1 day −1 saline, and all other groups were administered SCOP (1 mg kg −1 day −1, i.p.) 1 h after barbigerone p.o. treatment. The spontaneous alternation activities, learning capacities of a rat's memory were tested with Morris water maze and Y-maze. Reduced glutathione, malondialdehyde, acetylcholine esterase (AChE) and catalase (CAT) levels were measured in rat brain tissue as oxidative stress/antioxidant markers. Moreover, the levels of tumour necrosis factor, interleukin-6 (IL-6) and IL-1 β were also estimated. Treatment with barbigerone in SCOP-administered rats dramatically reduced SCOP-induced neurobehavioural deficits, oxidative stress and neuroinflammatory markers, improved endogenous antioxidants, and restored AChE activity. By improving cholinergic function and reducing oxidative damage, barbigerone could mitigate the effects of SCOP-induced changes in the brain.