Differential Effects of Transcranial Static Magnetic Stimulation Over Left and Right Dorsolateral Prefrontal Cortex on Brain Oscillatory Responses During a Working Memory Task. (1st May 2023)

• Record Type: Journal Article
• Authors: Watanabe, Tatsunori; Chen, Xiaoxiao; Yunoki, Keisuke; Matsumoto, Takuya; Horinouchi, Takayuki; Ito, Kanami; Ishida, Haruki; Sunagawa, Toru; Mima, Tatsuya; Kirimoto, Hikari
• Is Part Of: Neuroscience. Volume 517(2023)
• Page Start: 50
• Page End: 60
• Publication Date: 2023-05-01
• Subjects: transcranial static magnetic stimulation -- non-invasive brain stimulation -- dorsolateral prefrontal cortex -- working memory -- event-related synchronization -- event-related desynchronization; DLPFC dorsolateral prefrontal cortex -- EEG electroencephalogram -- ERD event-related desynchronization -- ERS event-related synchronization -- NIBS non-invasive brain stimulation -- rTMS repetitive TMS -- tDCS transcranial direct current stimulation -- TMS transcranial magnetic stimulation -- tSMS transcranial static magnetic stimulation -- WM working memory; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2023.03.006
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Effect of transcranial static magnetic stimulation (tSMS) on DLPFC was examined. Working memory was impaired by tSMS over the left and right DLPFC. The degree of impairment was similar between the left and right stimulations. TSMS over the left DLPFC increased beta-band event-related synchronization. TSMS over the right DLPFC did not show such a change in brain oscillations. Abstract: Transcranial static magnetic stimulation (tSMS) is known to influence behavioral and neural activities. However, although the left and right dorsolateral prefrontal cortex (DLPFC) are associated with different cognitive functions, there remains a lack of knowledge on a difference in the effects of tSMS on cognitive performance and related brain activity between left and right DLPFC stimulations. To address this knowledge gap, we examined how differently tSMS over the left and right DLPFC altered working memory performance and electroencephalographic oscillatory responses using a 2-back task, in which subjects monitor a sequence of stimuli and decide whether a presented stimulus matches the stimulus presented two trials previously. Fourteen healthy adults (five females) performed the 2-back task before, during (20 min after the start of stimulation), immediately after, and 15 min after three different stimulation conditions: tSMS over the left DLPFC, tSMS over the right DLPFC, and sham stimulation. Our preliminary results revealed that while tSMS over the left and right DLPFC impaired working memory performance to a similar extent, the impacts of tSMS on brain oscillatory responses were different between the left and right DLPFC stimulations. Specifically, tSMS over the left DLPFC increased the event-related synchronization in beta band whereas tSMS over the right DLPFC did not show such an effect. These findings support evidence that the left and right DLPFC play different roles in working memory and suggest that the neural mechanism underlying the impairment of working memory by tSMS can be different between left and right DLPFC stimulations.