Cover Feature: In Vivo Applications of Bioorthogonal Reactions: Chemistry and Targeting Mechanisms (Chem. Eur. J. 20/2023). Issue 20 (9th March 2023)

• Record Type: Journal Article
• Authors: Mitry, Madonna M. A.; Greco, Francesca; Osborn, Helen M. I.
• Is Part Of: Chemistry. Volume 29:Issue 20(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-09
• Subjects: bioorthogonal chemistry -- click chemistry -- in vivo -- metabolic glycoengineering; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202300691
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Bioorthogonal chemistry refers to reactions that can proceed in biological systems without interfering with biological processes. It has enabled the study of biomolecules in their native environment and has facilitated advanced imaging and diagnostic applications. In their Review (DOI: 10.1002/chem.202203942 ), M. M. A. Mitry, F. Greco and H. M. I. Osborn critically appraise the suitability of bioorthogonal reactions for in vivo applications. Areas of focus are chemical reactions and the targeting mechanisms used to deliver the bioorthogonal reactions' components.