Cover Feature: Theoretical Studies of Mutual Effects between 6‐m‐r Hemiketalization and 26‐m‐r Lactonization in Pimaricin Thioesterase (Chem. Asian J. 7/2023). Issue 7 (8th March 2023)

• Record Type: Journal Article
• Authors: Jiang, Chuchu; Zhou, Yucong; Tao, Wentao; Ji, Shunjia; Mao, Yong; Shi, Ting; Zheng, Jianting; Bai, Linquan; Zhao, Yi‐Lei
• Is Part Of: Chemistry, an Asian journal. Volume 18:Issue 7(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-08
• Subjects: cyclization -- hemiketal -- macrolactone -- pimaricin -- thioesterase; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.202300133
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract : Cooperation between 6‐m‐r hemiketalization and 26‐m‐r macrolactonization is reported for a thioesterase (pimTE) in type‐I polyketide synthase. Intriguingly, the R‐hemiketal intermediate is not only catalyzed by the D179 residue, but also twists the substrate hairpin structure to the 26‐m‐r lactonizing pre‐reaction state. Thus, pimTE is believed to be a bifunctional enzyme, which can synergistically catalyze tandem 6‐m‐r and 26‐m‐r formations during the main‐chain release of pimaricin biosynthesis. More information on this study can be found in the Research Article by Linquan Bai, Yi‐Lei Zhao et al.