Innentitelbild: Strukturelle und mechanistische Studien zur Substrat‐ und Stereoselektivität der Indol‐Monooxygenase VpIndA1: Neue Wege für biokatalytische Epoxidationen und Sulfoxidationen (Angew. Chem. 17/2023). (15th March 2023)

• Record Type: Journal Article
• Authors: Kratky, Julia; Eggerichs, Daniel; Heine, Thomas; Hofmann, Sarah; Sowa, Philipp; Weiße, Renato H.; Tischler, Dirk; Sträter, Norbert
• Is Part Of: Angewandte Chemie. Volume 135:Number 17(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-15
• Subjects: Biokatalyse -- Flavoenzyme -- Monooxygenase -- Proteinkristallographie -- Strukturbasiertes Enzymdesign; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202303193
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract : A flavin‐dependent group E monooxygenase ("GEM") has been characterized by crystal‐structure analysis, computational and kinetic studies to reveal substrate binding and mechanistic details for this class of enzymes for the first time. Based on these data, Dirk Tischler, Norbert Sträter, and co‐workers redesigned the substrate binding pocket to synthesize chiral epoxides and sulfoxides with high stereoselectivity, a true treasure of molecular gems, as described in their Research Article (e202300657) .