Friends or foes: The mononuclear phagocyte system in ischemic stroke. (8th February 2023)

• Record Type: Journal Article
• Authors: Ziqing, Zhang; Yunpeng, Liu; Yiqi, Liu; Yang, Wang
• Other Names: Zeng Xianwei guestEditor.; Slevin Mark guestEditor.; Tu Wen‐Jun guestEditor.
• Is Part Of: Brain pathology. Volume 33:Number 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-08
• Subjects: immune response -- inflammatory markers -- ischemic stroke -- mononuclear phagocyte system; Nervous system -- Diseases -- Periodicals; Brain -- Diseases -- Periodicals; Neurology -- Periodicals; Brain Diseases -- Periodicals; Cerveau -- Maladies -- Périodiques; Système nerveux -- Maladies -- Périodiques; Neurologie -- Périodiques; 616.805
• DOI: 10.1111/bpa.13151
• Languages: English
• ISSNs: 1015-6305

Abstract

Abstract: Ischemic stroke (IS) is a major cause of disability and death in adults, and the immune response plays an indispensable role in its pathological process. After the onset of IS, an inflammatory storm, with the infiltration and mobilization of the mononuclear phagocyte system (MPS), is triggered in the brain. Microglia are rapidly activated in situ, followed by waves of circulating monocytes into the ischemic area. Activated microglia and monocytes/macrophages are mainly distributed in the peri‐infarct area. These cells have similar morphology and functions, such as secreting cytokines and phagocytosis. Previously, the presence of the MPS was considered a marker of an exacerbated inflammatory response that contributes to brain damage. However, recent studies have suggested a rather complicated role of the MPS in IS. Here, we reviewed articles focusing on various functions of the MPS among different phases of IS, including recruitment, polarization, phagocytosis, angiogenesis, and interaction with other types of cells. Moreover, due to the characteristics of the MPS, we also noted clinical research addressing alterations in the MPS as potential biomarkers for IS patients for the purposes of predicting prognosis and developing novel therapeutic strategies. Abstract : Pathophysiological effects of mononuclear phagocyte system MPS in ischemic stroke.