Negative 68Ga–Prostate-Specific Membrane Antigen PET/CT Scan on a Recurrent Juvenile Nasopharyngeal Angiofibroma. (March 2022)

• Record Type: Journal Article
• Authors: Chandran, Aswin; Verma, Hitesh; Bhalla, Ashu Seith; Kumar, Rakesh; Kakkar, Aanchal
• Is Part Of: Clinical nuclear medicine. Volume 47:Number 3(2022)
• Publication Date: 2022-03
• Subjects: angiofibroma -- juvenile nasopharyngeal angiofibroma -- MRI -- PSMA PET-CT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003965
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: We present the case of a left-sided recurrent juvenile nasopharyngeal angiofibroma (JNA) in a 16-year-old boy who underwent endoscopic excision 2 years back. The preoperative contrast-enhanced MRI and histopathology were in favor of JNA. The follow-up 68 Ga–prostate-specific membrane antigen (PSMA) PET/CT scan at 3-month interval revealed complete clearance of disease. Currently, the patient presented with recurrent bleeding and nasal endoscopic examination, and contrast-enhanced MRI revealed a presence of a recurrent tumor. The tumor did not show any uptake on 68 Ga-PSMA PET/CT, and postoperative histopathology evaluation confirmed the presence of JNA. Although regarded as a criterion-standard imaging modality for assessment of recurrent or residual JNA, 68 Ga-PSMA PET/CT is never 100% specific.