Trichodysplasia spinulosa: a polyomavirus infection specifically targeting follicular keratinocytes in immunocompromised patients. (1st March 2016)

• Record Type: Journal Article
• Authors: Rouanet, J.; Aubin, F.; Gaboriaud, P.; Berthon, P.; Feltkamp, M.C.; Bessenay, L.; Touzé, A.; Nicol, J.T.J.; Franck, F.; D'Incan, M.
• Is Part Of: British journal of dermatology. Volume 174:Number 3(2016)
• Page Start: 629
• Page End: 632
• Publication Date: 2016-03-01
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.14346
• Languages: English
• ISSNs: 0007-0963

Abstract

Summary: Trichodysplasia spinulosa (TS) is a rare skin disease, caused by a specific polyomavirus, occurring in immunocompromised patients. The pathophysiological mechanisms of TS are not yet fully understood. By using polymerase chain reaction and skin biopsy immunostaining we report evidence, in a paediatric case, of follicular keratinocytes being the primary target of trichodysplasia spinulosa‐associated polyomavirus.