Theoretical and experimental comparison of the performance of gold, titanium, and platinum nanodiscs as contrast agents for photoacoustic imaging. Issue 14 (23rd March 2023)

• Record Type: Journal Article
• Authors: Wi, Jung-Sub; Kim, Jiwoong; Kim, Myeong Yun; Choi, Seongwook; Jung, Hae Jue; Kim, Chulhong; Na, Hee-Kyung
• Is Part Of: RSC advances. Volume 13:Issue 14(2023)
• Page Start: 9441
• Page End: 9447
• Publication Date: 2023-03-23
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d3ra00795b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Nanodiscs with different materials but the same shape and size were synthesized, and their performance as photoacoustic imaging contrast agents was compared both theoretically and experimentally. Abstract : Exogenous contrast agents in photoacoustic imaging help improve spatial resolution and penetration depth and enable targeted molecular imaging. To screen efficient photoacoustic signaling materials as contrast agents, we propose a light absorption-weighted figure of merit (FOM) that can be calculated using material data from the literature and numerically simulated light absorption cross-sections. The calculated light absorption-weighted FOM shows that a Ti nanodisc has a photoacoustic conversion performance similar to that of an Au nanodisc and better than that of a Pt nanodisc. The photoacoustic imaging results of Ti, Au, and Pt nanodiscs, which are physically synthesized with identical shapes and dimensions, experimentally demonstrated that the Ti nanodisc could be a highly efficient contrast agent.